KPV | Alpha-MSH C-Terminal Tripeptide

Research Overview

KPV is a C-terminal tripeptide fragment of alpha-melanocyte stimulating hormone (alpha-MSH), specifically the sequence Lysine-Proline-Valine. It acts on melanocortin receptors and has been studied for its anti-inflammatory properties in research models.

Research has investigated KPV’s interactions with MC1R and MC3R receptors, its effects on NF-κB signaling pathways in cell models, and its potential applications in models of inflammatory bowel conditions and skin inflammation in animals. Studies have examined its ability to cross the blood-brain barrier and its central anti-inflammatory effects.

Select Published Research

Ceriani G et al. (1994). “Central neurogenic anti-inflammatory action of alpha-MSH: modulation of peripheral inflammation.” Neuroendocrinology.
Dalmasso G et al. (2008). “The peptide KPV has anti-inflammatory properties in vitro and in vivo.” Inflammatory Bowel Diseases.
Adan RA et al. (2006). “Melanocortin receptors as drug targets.” Drug Discovery Today.

All referenced studies were conducted in animal models or in vitro. These citations do not constitute claims of human efficacy or safety.

Specifications

Format: Lyophilized powder
Purity: >98% verified by HPLC and mass spectrometry
Storage: −20°C lyophilized. Reconstituted: 4°C, use within 30 days.
Source: Domestically synthesized

Certificate of Analysis

Third-party COA available in the Lab Results tab above.